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KMID : 1151920210030020060
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Chronobiology in Medicine
2021 Volume.3 No. 2 p.60 ~ p.63
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Association of Circadian Clock and Severe Acute Respiratory Syndrome Coronavirus 2 Infection
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Tomar Renu
Raghav Alok
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Abstract
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing devastation worldwide accounting millions of deaths. This virus is among the new member of the Coronaviridae family with differences from SARS-CoV. The entry of the virus to human cells mediated through spike (S) proteins with angiotensin-converting enzyme 2 (ACE2). Several comorbidities such as hypertension, diabetes, HIV, malignancy, diabetes, chronic respiratory disease, and cardiovascular disease makes a person susceptible to COVID-19 infection. Circadian rhythm/oscillations or biological clock plays important role in the pathogenesis of SARS-CoV-2 infection mediated through ACE2 and BMAL1.
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KEYWORD
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Severe acute respiratory syndrome coronavirus 2, Hypertension, Diabetes mellitus, Circadian rhythm, Oscillations
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